We use cookies on this website. See how you can control your settings.

About us | Sitemap | Links | Accessibility | Copyright | Contact us | News | Video | Kidneypedia | Kidney disease | Kidney treatment | Patient lifestyle | Research |

News from the Kidney Services at Guy's and King's

The ONE Study

Over the last half century kidney transplantation has become ever more successful and is now the best treatment for many kidney patients. Early results are outstanding and people usually leave hospital with a well functioning new kidney and quickly return to an active life.

However the immmune system can reject and destroy the new kidney, even after many years. To prevent this, immune suppressing drugs are used to damp down the immune response, but these drugs have side effects such as making transplant patients more vulnerable to infection and to certain types of cancer. People may still experience transplant rejection and may lose their kidney even when using the newest and most powerful immune suppressing drugs.

Doctors and scientists at Guy's Hospital have been looking at different ways of controlling the immune system without immune suppressing drugs, a situation called TOLERANCE. The ONE Study is a new research study into a more natural way of suppressing the immune system in kidney transplant patients.

During the study blood is taken from people who are scheduled to receive a kidney transplant from a living donor. The white cells are then separated from the red cells and among the white cells an immune suppressing cell called a regulatory T cell is identified. These cells will be grown in the laboratory and five days after the kidney transplant they will given back to the tranplant recipient  via a 'drip'. Doctors want to see whether the cells will survive in the patient and whether they can alter the immune system so that rejection is less likely. If successful this would allow the use of lower doses and fewer immune suppressing drugs so that patients would experience fewer side effects.

Please conatct Dr Rachel Hilton or Dr David Game for more information: Rachel.hilton@gstt.nhs.uk or  David.game@gstt.nhs.uk